Liver-targeted gene therapy improves Alzheimer's symptoms in mice: Study

Researchers at Gladstone Institute found the blood-brain barrier actively selects proteins entering the brain, including APOA1 and AAT linked to Alzheimer's. In mice with Alzheimer's-like symptoms, APOA1 levels dropped while AAT rose. Boosting APOA1 via liver-targeted gene therapy improved symptoms in these mice, suggesting a potential new treatment pathway for Alzheimer's.