Scientists trigger testis development in female mice with single DNA tweak

Female mouse embryos with a single 'letter' change in a specific DNA region develop male reproductive organs, a study published in Nature Communications found. The study showed that modifying both copies of enhancer 13 (Enh13), which controls SOX9, causes female mice to develop male genitals and small testes. However, those with one modified copy of Enh13 still developed female organs.