What are the hidden interactions of grapefruit and medicines?

According to dietitian Garima Verman, proof-based insight says grapefruit contains bioactive compounds that inhibit intestinal and hepatic CYP3A4 enzymes, altering pharmacokinetics of many drugs. Mechanism can elevate systemic concentrations or reduce effectiveness, necessitating clinical awareness. Careful review of grapefruit-drug interaction mechanisms underscores importance of enzyme dynamics.