Antibiotic resistance is rising due to overuse, threatening future treatments. Dr Umang Agrawal, Infectious Diseases Consultant at P D Hinduja Hospital, stresses antibiotic stewardship to curb this crisis. Responsible prescribing, patient awareness, and preventive practices can help safeguard these drugs. Without action, antimicrobial resistance may cause 39 million deaths between 2025 and 2050.