Tamil Nadu’s 20,957 septicaemia deaths exceed the combined totals of Karnataka (4,325), Andhra (4,060), Telangana (1,775), Kerala (650), and Puducherry (1,460), altogether accounting for 12,270 deaths. TN alone records 70.7% more septicaemia deaths than its neighbours combined. Septicaemia occurs when bacteria or other pathogens enter the bloodstream and trigger a systemic inflammatory response.